Do There Exist Innovative Perspectives in Tissue Engineering-Based Ligament Reconstruction?

Do There Exist Innovative Perspectives in Tissue Engineering-Based Ligament Reconstruction?

Reconstruction of musculoskeletal tissues requires innovative strategies, which need to be developed by experimental research. As much as possible the application of tailored and optimized in vitro models based on human-derived cell sources should be expanded to substitute and scale down animal experiments and to collect sufficient information for the concerted selection of the most suitable an...

Tissue Engineering: a Potential Therapy for Anterior Cruciate Ligament Reconstruction

Anterior cruciate ligament (ACL) ruptures are common among active individuals. The avascular structure of ligaments prevents natural healing; therefore, reconstructive surgery is often performed. Current surgical options include use of either an autograft composed of the patient’s hamstring tendons or bonepatellar tendon-bone complex (BPTB), or an allograft composed of a cadaver BPTB. Despite i...

Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst r...

Tissue Engineering: Oromaxillofacial reconstruction with platelet rich plasma (PRP)

Innovative Strategies for Tissue Engineering

Unmet need. It is beyond dispute that human population is ageing. For the first time in history, people age 65 and over will outnumber children under age 5. This trend is emerging around the globe, and will bring several challenges for health technologies. For instance, in a few decades, the loss of health and life worldwide will be greater from chronic diseases than from infectious diseases an...